Catalog # GX5805

phospho-Girdin (Tyr-1764) Peptide

Blocking Peptide

Application / Dilution
ELISA50 ng/well

Size 50 μg



Girdin, a member of the CCDC88 (Hook related protein) family, is an actin binding protein involved with cell migration and maintaining cytoskeletal organization. Girdin has conserved domains at the N- and C-terminus that bind microtubules and actin, respectively. It enhances PI3-kinase dependent phosphorylation of proteins, most notably Akt. This same activity can contribute to tumor proliferation, invasion, and metastasis in breast, ovarian, prostate, and pancreatic tissues. Girdin is phosphorylated at three separate locations: Ser-1416, Ser-1674, and Tyr-1764. Ser-1416 is the primary Akt phosphorylation site, while Cyclin-dependent kinases interact with Girdin and phosphorylate Ser-1674. Multiple receptor tyrosine kinases can bind girdin and phosphorylate Tyr-1764.



Bhandari, D. et al. (2015)Proc Natl Acad Sci. 112(35):E4874
Hayano S. et al, (2015) J Mol Cell Cardiol. 88:55
Lin, C. et al. (2014) Mol Biol Cell. 25(22):3654
Simpson, F. (2005) Traffic. 6(6):442

Phospho-Girdin (Tyr-1764) synthetic peptide corresponding to amino acid residues around tyrosine 1764 in human Girdin. This sequence has high homology to rat and mouse Girdin, and the site is not conserved in other Girdin family members.

*For more information, see UniProt Accession Q3V6T2
Blocking Peptide is supplied in 50µl phosphate-buffered saline and 0.05% sodium azide.

The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.

The peptide is specifically recognized by Girdin (Tyr-1764), phospho-specific antibody (GP5801) in ELISA, and has been shown to block the reactivity of GP5801 in Western blot. In addition, the peptide is recommended for use in blocking GP5801 reactivity in immunocytochemistry.

*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.

This kit contains: