Catalog # WP3931
Size 100 μl
Species Reactivity Hu, Rt, Ms, Ck
MW 110 kDa
The Nedd4-like family of E3 ubiquitin ligases have been implicated in several types of human cancer. There are nine members of the Nedd4-like E3 family, all of which have an N-terminal C2 domain, two to four WW domains in the central region, and a C-terminal domain that is homologous to the C-terminus of E6-AP. This ubiquitin ligase family includes NEDD4-1, NEDD4-2, AIP4/Itch, AIP5/WWP1, SMURF1 and SMURF2. Several ubiquitin ligases in this family are overexpressed in human cancers. WWP1 has been implicated as an oncogene as it is overexpressed in prostate and breast cancers, and knockdown of this ligase reduces cell proliferation and causes apoptosis. In addition, WWP1 has been shown to negatively regulate transforming growth factor-β (TGFβ) signaling by targeting TGFβ receptor 1, Smad2, and Smad4 for ubiquitin-mediated degradation. WWP1 has also been shown to regulate the protein levels of the epithelial sodium channel (ENaC), Notch, EGFR/ErbB2, Runx2, KLF2, KLF5, p53, and p63. Thus, WWP1 may regulate cell development and proliferation through the degradation of proteins involved in a variety of cell signaling pathways.
Chen, C. et al. (2009) Int. J. Cancer 124:2829.
Chen, C. et al. (2005) J. Biol. Chem. 280(50):41553.
Komuro, A. et al. (2004) Oncogene 23:6914.
Pirozzi, G. et al. (1997) J. Biol. Chem. 272:14611.
*For more information, see UniProt Accession Q9H0M0
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: