Cellular processes such as proliferation, differentiation, and cell migration are directed through the highly regulated control of transcriptional cofactors. During cell migration, serum response factor (SRF) is a central transcription factor that interacts with MAL to induce gene expression in response to actin assembly changes caused by the RhoA-mDia1 pathway. SCAI (suppressor of cancer cell invasion) is a highly conserved protein that is thought to regulate invasive cell migration and act on the RhoA–mDia1 signal transduction pathway. SCAI localizes in the nucleus, where it is thought to bind and inhibit MAL, by forming a ternary complex with SRF. Suppression of SCAI expression has been shown to upregulate β1-integrin expression, an intergrin that is also upregulated in several human malignancies. In addition, SCAI is downregulated in various human tumors, and decreased levels of SCAI correlate with increased invasive cell migration. Thus, SCAI is a transcriptional cofactor that may be important for regulating gene expression downstream of mDia1 to direct changes in cell motility.
Brandt, D.T. et al. (2009) Cell Cycle. 8(16):2523.
Brandt, D.T. et al. (2009) Nat Cell Biol. 11(5):557.
*For more information, see UniProt Accession Q8C8N2
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
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