Catalog # SM1481
Stat5 (Tyr-694), phospho-specific Antibody
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 92 kDa
The stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Stat5 is activated in response to a wide variety of ligands including IL-2, GM-CSF, growth hormone and prolactin. Phosphorylation at Tyr-694 is required for Stat5A activation. Stat5 has been found to be constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility. Both Stat5A (Tyr-694) and Stat5B (Tyr-699) are independently regulated and activated in various cell types. For instance, both isoforms are activated in response to IFNα in B cells, but only Stat5A is phosphorylated in response to IFNα in HeLa cells.
Darnell, J.E. (1997) Science 277:1630.
Meinke, A. et al. (1996) Mol. Cell. Biol. 16:6937-6944.
Gouilleux, F. et al. (1994) EMBO J. 13:4361.
Wakao, H. et al. (1994) EMBO J. 13:2182.
*For more information, see UniProt Accession P42229
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: