Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Serine phosphorylation of paxillin occurs in response to growth-factor activation and fibronectins. Both JNK1 and cdc2 kinases can phosphorylate serine 178 in paxillin. The mutant form of paxillin (S178A) decreases the migration of keratocytes and epithelial cells. Thus, phosphorylation paxillin at serine 178 may be important during cell migration.
Huang, C. et al. (2004) Cell Cycle 3(1):4-6.
Huang, C. et al. (2003) Nature 424:219-223.
Woodrow, M.A. (2003) Exp. Cell. Res. 287(2):325-338.
*For more information, see UniProt Accession P49023
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
Product References:Chen, M.J. et al. (2020) Am J Cancer Res. 10(1):275. (IHC, WB: S178A mutant)
Wu, D. W. et al. (2014) Oncogene 33(35): 4385. (WB: CCM3 cells)
Wei, W. et al. (2013) Pancreatology 13(4):384. (WB: pancreatic PANC1, Capan-2 and HT1080 cells)
Liu, H. et al. (2013) BMC Cancer. 13:80. (WB: human ovarian cancer cells)
Kwak, T.K. et al. (2010) J Biol Chem. 285(46):36021. (WB: pancreatic INS-1 cells)
This kit contains: