Catalog # NP2111
Neuropilin-1 (a1 CUB Domain)
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 130 kDa
Neuropilins are transmembrane proteins that contain two CUB domains (a1 and a2), two coagulation factor-like domains (b1 and b2), and a MAM domain in the extracellular region. These proteins have short cytoplasmic domains that include a PDZ-binding motif. The neuropilin (NRP) family includes NRP-1, NRP-2A, and NRP-2B. NRP-1 has been implicated as a receptor involved in axon guidance and VEGF signaling. NRP-1 mediates activation of intracellular signaling pathways through interaction with its co-receptors, Plexin-A1 and VEGFRs. The expression of NRP-1, along with the co-receptor Plexin-A1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.
Nakamura, F. & Goshima, Y. (2002) Adv Exp Med Biol. 515:55.
Takahashi, T. et al. (1999) Cell 99:59.
He, Z. & Tessier-Lavigne, M. (1997) Cell 90:739.
*For more information, see UniProt Accession O14786
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
Product References:Shimogawa, T. et al. (2019) NPJ Regen Med. 4:13. (IHC: rat cortical neurons)
Sano, N. et al. (2017) Front Cell Neurosci. 11:123. (ICC: mouse cortical neurons)
Boro, A. et al. (2015) Am J Transl Res. 7(3):640-653 (WB: human osteosarcoma cell lines)
Ohkusu-Tsukada, K. et al. (2010) Int J Cancer. Epub 15 MAR. (ELISA: sNRP1 mouse serum)
Drenberg, C.D. et al. (2009) Obstet Gynecol Intl. 2009:1-8. (IHC: human ovarian tissues)
Saban, M.R. et al. (2008) AJP Renal Phys. 295(1):F60. (ICC: human urothelium)
This kit contains: