Neuropilins are transmembrane proteins that contain two CUB domains (a1 and a2), two coagulation factor-like domains (b1 and b2), and a MAM domain in the extracellular region. These proteins have short cytoplasmic domains that include a PDZ-binding motif. The neuropilin (NRP) family includes NRP-1, NRP-2A, and NRP-2B. NRP-1 has been implicated as a receptor involved in axon guidance and VEGF signaling. NRP-1 mediates activation of intracellular signaling pathways through interaction with its co-receptors, Plexin-A1 and VEGFRs. The expression of NRP-1, along with the co-receptor Plexin-A1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.
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*For more information, see UniProt Accession O14786
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
Product References:Shimogawa, T. et al. (2019) NPJ Regen Med. 4:13. (IHC: rat cortical neurons)
Sano, N. et al. (2017) Front Cell Neurosci. 11:123. (ICC: mouse cortical neurons)
Boro, A. et al. (2015) Am J Transl Res. 7(3):640-653 (WB: human osteosarcoma cell lines)
Ohkusu-Tsukada, K. et al. (2010) Int J Cancer. Epub 15 MAR. (ELISA: sNRP1 mouse serum)
Drenberg, C.D. et al. (2009) Obstet Gynecol Intl. 2009:1-8. (IHC: human ovarian tissues)
Saban, M.R. et al. (2008) AJP Renal Phys. 295(1):F60. (ICC: human urothelium)
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