![Integrin β1 (Extracellular region) M006 Antibody](http://ecmbio.com/cdn/shop/products/Icon_GOmAbred2_text2_9aad1c2a-7979-4231-a18a-1d5808c37220_compact.png?v=1597167327)
Catalog # IM0061
Integrin β1 (Extracellular region) M006 Antibody
Mouse Monoclonal
ELISA | 1:2000 |
ICC | 1:100 |
IP | 1:100 |
WB | 1:1000 |
Size 100 μl
Species Reactivity Hu
MW 130 kDa
Isotype IgG2a
Integrins are cell adhesion molecules that can mediate bidirectional transfer of signals across the plasma membrane. The cytoplasmic domains of integrin family members interact with components of the signal transduction apparatus within cells. Integrin receptors contain noncovalently associated α and β subunits that consist of a large extracellular region (the ligand-binding domain), a short transmembrane region, and a cytoplasmic domain of varying length. In mammals, at least 17 α subunits and 8 β subunits have been identified and these proteins can heterodimerize to form at least 22 different receptors. The β1 subfamily includes 12 distinct integrin proteins that bind to different extracellular matrix molecules. Integrin β1 has been implicated in various activities including embryonic development, blood vessel, skin, bone, and muscle formation, as well as tumor metastasis and angiogenesis.
References
Iwamoto, D. & Calderwood, D. (2015) Cur Opin Cel Bio. 36:41.
Wang, L. et al. (2012) J Cell Physiol. 227(2):474.
![](https://cdn.shopify.com/s/files/1/0016/1021/9589/files/Integrinb1_IM0061den.jpg)
Western blot analysis of native (lanes 1-3) and denatured (lanes 4-6) cell lysates from human A431 (lane 1 & 4), A549 (lane 2 & 5), and MDA-MB-231 (lane 3 & 6). The blots were probed with mouse monoclonal anti-Integrin β1 (IM0061) at 1:1000 dilution.
![](https://cdn.shopify.com/s/files/1/0016/1021/9589/files/Integrinb1_IM0061_6b0f2a02-8e53-4daa-90f0-c50e251e69c9.jpg?11339748804131525062)
Immunocytochemical labeling of Integrin β1 in paraformaldehyde fixed human A431 cells. The cells were labeled with mouse monoclonal anti-Integrin β1 (clone M006). The antibody was detected using goat anti-mouse DyLight® 594.
*For more information, see UniProt Accession P05556
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: