Antibodies for Immunotherapy Research

Cancer cells that overcome immune defenses establish a tumor-promoting microenvironment that fosters tumor growth and metastasis - the primary cause of mortality in most cancers. Cancer researchers are rapidly identifying novel immune modulating receptors and ligands expressed by cancer, immune, and stromal cells within tumors. Novel therapies that target these immunosuppressive pathways are being developed, and some have already shown promise in the clinic, including B7.1/CTLA-4 and PD-L1/PD-1 therapies. More recently, other B7 family members, such as B7-H3 and B7-H4 have also been implicatedĀ in tumor mediated immune suppression.