Yes (N-terminal region) Antibody

c-Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. The Src family is composed of nine members in vertebrates, including c-Src, Yes, Fgr, Yrk, Fyn, Lyn, Hck, Lck, and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Src-family kinases contain an N-terminal cell membrane anchor followed by SH3 and SH2 domains. The activity of Src family kinases is regulated by tyrosine phosphorylation at multiple sites. Phosphorylation of conserved N-terminal and central region tyrosine residues promotes activation, while phosphorylation of conserved C-terminal tyrosine residues downregulates Src kinase activity. Thus, tyrosine phosphorylation of Src kinases is critical for regulating their activity.

References

*For more information, see UniProt Accession Q04736

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