Catalog # YM2501
Yes (N-terminal region)
Mouse Monoclonal
| ELISA | 1:2000 |
| WB | 1:1000 |
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 62 kDa
Isotype IgG1
c-Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. The Src family is composed of nine members in vertebrates, including c-Src, Yes, Fgr, Yrk, Fyn, Lyn, Hck, Lck, and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Src-family kinases contain an N-terminal cell membrane anchor followed by SH3 and SH2 domains. The activity of Src family kinases is regulated by tyrosine phosphorylation at multiple sites. Phosphorylation of conserved N-terminal and central region tyrosine residues promotes activation, while phosphorylation of conserved C-terminal tyrosine residues downregulates Src kinase activity. Thus, tyrosine phosphorylation of Src kinases is critical for regulating their activity.
References
*For more information, see UniProt Accession Q04736
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
Western blot analysis of human A431 (lane 1) and Jurkat (lane 2) cell lysates, as well as adult mouse brain tissue (lane 3). The Blot was probed with mouse monoclonal anti-Yes (N-terminal region) at 1:1000.
This kit contains:
