Catalog # TM3391
TRADD (C-terminal region) Antibody
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 34 kDa
Tumor necrosis factor (TNF) activates TNF receptor-1 (TNFR1), leading to diverse biological activities in many cell types. TNFR1 contains an intracellular death domain that is required for signaling related to antiviral activity, programmed cell death, and NF-κB activation. TNFR1-associated death domain protein (TRADD) was isolated in a screen to identify proteins that interact with the death domain of TNFR1. TRADD is a 34-kDa protein that contains a 111-amino acid death domain with sequence similarity to TNFR1. This domain mediates oligomerization of TRADD and interaction with TNFR1. TRADD mRNA is expressed ubiquitously, and overexpression of TRADD causes TNF-induced apoptosis and activation of NF-κB. These responses require the TRADD death domain. In addition to TNF signaling, TRADD N-terminus can interact with Stat1 in response to IFNγ, and this interaction can negatively regulate Stat activity.
Wesemann, D.R. et al. (2004) Nat. Immun. 5:199.
Hsu, H. et al. (1995) Cell 81:495.
*For more information, see UniProt Accession Q15628
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: