Catalog # SM3591
Smac/DIABLO (C-terminal region)
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 23 kDa
X linked inhibitor of apoptosis (XIAP) is a member of the inhibitor of apoptosis (IAP) family of proteins, and is involved in regulating programmed cell death by caspase inhibition. SMAC/DIABLO (second mitochondria derived activator of caspase/direct IAP binding protein with low PI) is expressed in a variety of tissues, and has been identified as a negative regulator of XIAP. A functionally active nine-residue peptide derived from the N terminus of Smac/DIABLO interacts with the baculovirus IAP repeat 3 domain of XIAP. Smac/DIABLO promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to IAPs and removing their inhibitory activity. Smac/DIABLO is normally a mitochondrial protein but is released into the cytosol when cells undergo apoptosis.
Du, C. et al. (2000) Cell 102:33.
Liu, Z. et al. (2000) Nature 408:1004.
Verhagen, A.M. et al. (2000) Cell 102:43.
*For more information, see UniProt Accession Q9NR28
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: