X linked inhibitor of apoptosis (XIAP) is a member of the inhibitor of apoptosis (IAP) family of proteins, and is involved in regulating programmed cell death by caspase inhibition. SMAC/DIABLO (second mitochondria derived activator of caspase/direct IAP binding protein with low PI) is expressed in a variety of tissues, and has been identified as a negative regulator of XIAP. A functionally active nine-residue peptide derived from the N terminus of Smac/DIABLO interacts with the baculovirus IAP repeat 3 domain of XIAP. Smac/DIABLO promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to IAPs and removing their inhibitory activity. Smac/DIABLO is normally a mitochondrial protein but is released into the cytosol when cells undergo apoptosis.
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Liu, Z. et al. (2000) Nature 408:1004.
Verhagen, A.M. et al. (2000) Cell 102:43.
*For more information, see UniProt Accession Q9NR28
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
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