The Ras family (K-Ras, H-Ras, and N-Ras) includes 21 kDa guanine-nucleotide binding proteins that cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAP kinase pathway. Both GTPase-activating proteins (GAPs), such as p120 Ras-GAP, and guanine-nucleotide exchange factors (GEFs) regulate the activity of Ras proteins in many cell signaling pathways. Mutations in Ras are found in several cancers, and the most common oncogenic mutation is Gly12 to Asp (G12D), which prevents Ras inactivation.
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*For more information, see UniProt Accession P01112
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
Product References:Wang, M. et al. (2011) Mol Cancer Res. 9(1)36. (WB: human protstate cells)
This kit contains: