Neuropilins are transmembrane proteins that contain two CUB domains (a1 and a2), two coagulation factor-like domains (b1 and b2), and a MAM domain in the extracellular region. These proteins have short cytoplasmic domains that include a PDZ-binding motif. The neuropilin (NRP) family includes NRP-1, NRP-2A, and NRP-2B. NRP-1 and NRP-2 can form a heterodimer. NRP-1 binds with high affinity to Semaphorin 3A, while NRP-2 binds with high affinity to Semaphorin 3F. Both NRP-1 and NRP-2 have been implicated in VEGFR and Plexin receptor function, and both neuropilins may be involved in axon guidance, angiogenesis, and tumor progression.
He, Z. & Tessier-Lavigne, M. (1997) Cell 90:739.
Kolodkin, A.L. et al. (1997) Cell 90:753.
*For more information, see UniProt Accession O35276
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: