Catalog # NM3911
Neuropilin-2 (MAM Domain) Antibody
Mouse Monoclonal
| ELISA | 1:2000 |
| WB | 1:500 |
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 130 kDa
Isotype IgG1
Neuropilins are transmembrane proteins that contain two CUB domains (a1 and a2), two coagulation factor-like domains (b1 and b2), and a MAM domain in the extracellular region. These proteins have short cytoplasmic domains that include a PDZ-binding motif. The neuropilin (NRP) family includes NRP-1, NRP-2A, and NRP-2B. NRP-1 and NRP-2 can form a heterodimer. NRP-1 binds with high affinity to Semaphorin 3A, while NRP-2 binds with high affinity to Semaphorin 3F. Both NRP-1 and NRP-2 have been implicated in VEGFR and Plexin receptor function, and both neuropilins may be involved in axon guidance, angiogenesis, and tumor progression.
References
He, Z. & Tessier-Lavigne, M. (1997) Cell 90:739.
Kolodkin, A.L. et al. (1997) Cell 90:753.
Western blot analysis of neuropilin-2 (NRP-2) expression in neonatal rat brain. The blot was probed with mouse monoclonal anti-NRP-2 (MAM Domain) at 1:250.
*For more information, see UniProt Accession O35276
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains:
