The stress-activated protein kinases (SAPK) or Jun-amino-terminal kinases (JNK) are potently activated by stressors such as UV and gamma radiation. Similar to other MAP Kinases, the core signaling unit is composed of a MAPKKK, usually MEKK1-4 or a mixed lineage kinase (MLK), which phosphorylate and activate MKK4-7, leading to dual phosphorylation and activation of JNK kinases. The MKK family member MKK4 (SEK1/JNKK1) is activated downstream of Rho-GTPases by MEKK or MLK phosphorylation of Ser-257 and Thr-261, while Akt phosphorylation of Ser-80 inhibits MKK4 and suppresses stress-activated signal transduction.
Kyriakis, J.M. et al. (1994) Nature 369:156.
Sanchez, I. et al. (1994) Nature 372:794.
Yan, M. et al. (1994) Nature 372:798.
*For more information, see UniProt Accession P45985
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: