Catalog # MM3361
MKK4 (N-terminal region)
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 44 kDa
The stress-activated protein kinases (SAPK) or Jun-amino-terminal kinases (JNK) are potently activated by stressors such as UV and gamma radiation. Similar to other MAP Kinases, the core signaling unit is composed of a MAPKKK, usually MEKK1-4 or a mixed lineage kinase (MLK), which phosphorylate and activate MKK4-7, leading to dual phosphorylation and activation of JNK kinases. The MKK family member MKK4 (SEK1/JNKK1) is activated downstream of Rho-GTPases by MEKK or MLK phosphorylation of Ser-257 and Thr-261, while Akt phosphorylation of Ser-80 inhibits MKK4 and suppresses stress-activated signal transduction.
Kyriakis, J.M. et al. (1994) Nature 369:156.
Sanchez, I. et al. (1994) Nature 372:794.
Yan, M. et al. (1994) Nature 372:798.
*For more information, see UniProt Accession P45985
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: