The Janus family of tyrosine kinases (Jak1, Jak2, Jak3 and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for several signaling proteins, such as Stats, Shc, and focal adhesion kinase (FAK). Thus, Jak kinases are important downstream mediators of cytokine signaling pathways.
Darnell, J.E. (1997) Science 277:1630.
*For more information, see UniProt Accession P52332
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: