Catalog # IM5841

Integrin αV (Extracellular region) Antibody

Mouse Monoclonal

Application / Dilution

Size 100 μl

Species Reactivity Hu, Rt, Ms

MW 125 kDa

Isotype IgG1



Integrins are cell adhesion molecules that can mediate bidirectional transfer of signals across the plasma membrane. The cytoplasmic domains of integrin family members interact with components of the signal transduction apparatus within cells. Integrin receptors contain noncovalently associated α and β subunits that consist of a large extracellular region (the ligand-binding domain), a short transmembrane region, and a cytoplasmic domain of varying length. In mammals, at least 17 α subunits and 8 β subunits have been identified and these proteins can heterodimerize to form at least 22 different receptors. The integrin β3 subunit associates with integrin α2 in platelets where this glycoprotein complex acts as a fibrinogen receptor and mediates platelet aggregation. In endothelial cells, integrin β3 complexes with the integrin αV subunit to form the vitronectin receptor. This receptor mediates endothelial cell adhesion to vitronectin, fibrinogen, von Willebrand factor, thrombospondin, laminin, and fibronectin.


Iwamoto, D, Calderwood, D.(2015) Curr Opin Cell Biol. 36:41.
Wang, L. et al. (2012) J Cell Physiol. 227(2):474.

Western blot analysis of human MDA-MB-231 cells. The blots were probed with mouse monoclonal anti-integrin αV (IM5841).

Clone M584 was generated from a recombinant protein containing amino acid residues in the extracellular region of human Integrin αV. This sequence has high homology with rat and mouse Integrin αV, and has low homology to other integrin family members.

*For more information, see UniProt Accession P06756
Mouse monoclonal antibody purified with protein A chromatography is supplied in 100µl phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide. Store at –20°C. Stable for 1 year.

The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.

This antibody detects a 125 kDa* protein corresponding to the molecular mass of Integrin αV on SDS-PAGE immunoblots of human MDA-MB-231 cells.

*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.

This kit contains: