Catalog # IM2881
ILK (C-terminal region)
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 51 kDa
Integrin-linked kinase (ILK) is an important downstream kinase for integrin and growth factor pathways. ILK interacts with several proteins including integrins, PINCH, CH-ILKBP, and affixin, to coordinate signaling from integrin and growth factor receptors. ILK phosphorylates Akt at Ser-473, GSK-3 at Ser-9, and myosin light chain 2 (MLC2) at Ser-18/Thr-19 to regulate the activity of these key signaling elements. ILK is activated through PI3 kinase and negatively regulated by the tumor suppressor PTEN and a PP2C protein phosphatase, ILKAP. Phosphorylation of ILK occurs at Thr-173, Ser-246, and Ser-343, and these modifications may be important for regulating ILK activity.
Morimoto, A.M. et al. (2000) Oncogene 19, 200-209.
Wu, C. and Dedhar, S. (2000) J. Biol. Chem. 155, 505-510.
*For more information, see UniProt Accession Q13418
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: