Integrin-linked kinase (ILK) is an important downstream kinase for integrin and growth factor pathways. ILK interacts with several proteins including integrins, PINCH, CH-ILKBP, and affixin, to coordinate signaling from integrin and growth factor receptors. ILK phosphorylates Akt at Ser-473, GSK-3 at Ser-9, and myosin light chain 2 (MLC2) at Ser-18/Thr-19 to regulate the activity of these key signaling elements. ILK is activated through PI3 kinase and negatively regulated by the tumor suppressor PTEN and a PP2C protein phosphatase, ILKAP. Phosphorylation of ILK occurs at Thr-173, Ser-246, and Ser-343, and these modifications may be important for regulating ILK activity.
Morimoto, A.M. et al. (2000) Oncogene 19, 200-209.
Wu, C. and Dedhar, S. (2000) J. Biol. Chem. 155, 505-510.
*For more information, see UniProt Accession Q13418
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: