Catalog # GM3331
GAP43 (N-terminal region) Antibody
Mouse Monoclonal
| ELISA | 1:2000 |
| ICC | 1:50 |
| IHC | 1:400 |
| WB | 1:1000 |
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 43 kDa
Isotype IgG1
GAP43 (B-50, F1, neuromodulin) is a phosphoprotein found in the presynaptic membranes of neurons, where it may have important roles in the maintenance of long-term potentiation and synaptic plasticity. Regulation of GAP43 activity may occur through PKC phosphorylation of Ser-41, which occurs during neurotransmitter release in mature neurons. Calmodulin may be a negative regulator of GAP43, since it binds to GAP43 when Ca2+ is low and neuronal activity is minimal. GAP43 is a major component of the growth cone in axons of developing neurons. Thus, it may have roles in axon development and synaptogenesis.
References
Gianotti, C. et al. (1992) Neuron 8:843.
McIntosh, H. et al. (1989) Visual Neuroscience 2:583.
Skene, J.H., et al. (1986) Science 233:783.
Western blot of mouse brain lysate. The blot was probed with mouse monoclonal anti-GAP43 (N-terminal region) antibody at 1:500 (lane 1) or 1:1000 (lane 2).
Formalin fixed, citric acid treated parafin sections of E7 chick spinal cord. Sections were probed with anti-GAP43 (GM3331) then anti-mouse:HRP before detection using DAB. (Image provided by Carl Hobbs and Dr. Pat Doherty at Wolfson Centre for Age-Related Diseases, King's College London).
*For more information, see UniProt Accession P17677
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains:
