GAP43 (B-50, F1, neuromodulin) is a phosphoprotein found in the presynaptic membranes of neurons, where it may have important roles in the maintenance of long-term potentiation and synaptic plasticity. Regulation of GAP43 activity may occur through PKC phosphorylation of Ser-41, which occurs during neurotransmitter release in mature neurons. Calmodulin may be a negative regulator of GAP43, since it binds to GAP43 when Ca2+ is low and neuronal activity is minimal. GAP43 is a major component of the growth cone in axons of developing neurons. Thus, it may have roles in axon development and synaptogenesis.
Gianotti, C. et al. (1992) Neuron 8:843.
McIntosh, H. et al. (1989) Visual Neuroscience 2:583.
Skene, J.H., et al. (1986) Science 233:783.
*For more information, see UniProt Accession P17677
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
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