Catalog # FM2381
Fyn (N-terminal region)
Mouse Monoclonal
| ELISA | 1:1000 |
| WB | 1:250 |
Size 100 μl
Species Reactivity Hu, Rt, Ms
MW 59 kDa
Isotype IgG2b
The Src family of tyrosine kinases include nine members in vertebrates, including c-Src, Yes, Fgr, Yrk, Fyn, Lyn, Hck, Lck, and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Fyn is a 59 kDa member of the Src family of tyrosine kinases that conatins a conserved carboxy terminus and unique N-terminal region. Fyn is N-myristoylated and targeted to the plasma membrane, where it is palmitoylated. Phosphorylation regulates the activity of Fyn at conserved residues, Tyr-420 and Tyr-531. Fyn clusters in caveolae-like membrane microdomains and can interact with a variety of other signaling molecules. Fyn activity is important during T cell receptor signaling, neuronal synaptic transmission, and adhesion-mediated signaling.
References
Thomas, S.M. & Brugge, J.S. (1997) Annu Rev Cell Dev Biol 13:513.
Hunter, T. (1987) Cell 49:1.
*For more information, see UniProt Accession P06241
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
Western blot analysis of adult mouse brain tissue lysate. The blot was probed with mouse monoclonal anti-Fyn (N-terminal region) at 1:125 (lane 1) and 1:500 (lane 2).
This kit contains:
