The Src family of tyrosine kinases include nine members in vertebrates, including c-Src, Yes, Fgr, Yrk, Fyn, Lyn, Hck, Lck, and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Fyn is a 59 kDa member of the Src family of tyrosine kinases that conatins a conserved carboxy terminus and unique N-terminal region. Fyn is N-myristoylated and targeted to the plasma membrane, where it is palmitoylated. Phosphorylation regulates the activity of Fyn at conserved residues, Tyr-420 and Tyr-531. Fyn clusters in caveolae-like membrane microdomains and can interact with a variety of other signaling molecules. Fyn activity is important during T cell receptor signaling, neuronal synaptic transmission, and adhesion-mediated signaling.
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*For more information, see UniProt Accession P06241
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: