The Desmoglein family of transmembrane glycoproteins include desmoglein 1, 2, and 3. Desmoglein-1 (Dsg1, CDHF4) is found in specialized plasma membrane junctions known as desmosome junctions. These junctions serve as membrane anchorage domains for intermediate filaments and microfilaments. Actin microfilaments anchor at adherens junctions to form an array of junction sizes, shapes, and positions. These junctions generally contain E- or N-Cadherins whose cytoplasmic regions are associated with cytoplasmic proteins such as α- and β- catenins, vinculin, α-actinin, and radixin. Intermediate filaments (IFs) are anchored at desmosomes by the desmosome-specific cadherin family members, desmocollin and desmoglein. These proteins associate with cytoplasmic proteins such as desmoplakin and plakoglobin (γ-Catenin). Plakoglobin is the only junctional protein found at both desmosomes and adherens junctions and, therefore, plays a crucial role in cell adhesion.
Wheeler, GN, et al. (1991) PNAS. 88(11):4796.
*For more information, see UniProt Accession Q02413
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: