Catalog # AM3341
Abp1 (C-terminal region)
Size 100 μl
Species Reactivity Hu
MW 55 kDa
Cellular morphology, adhesion, and motility occur through dynamic reorganization of actin-based superstructures. Actin-binding proteins are critical for regulating actin polymerization and superstructure formation. The Arp2/3 complex is an actin polymerization-inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20 Arc, and p16-Arc. Several actin binding proteins, WASP, cortactin, and Abp1, regulate the activity of the Arp2/3 complex. Abp1 (SH3P7, HIP-55) is the mammalian homologue of the yeast Abp1p, which has been shown to bind actin and to have roles in endocytosis. Abp1 contains a C-terminal Src homology 3 domain and an N-terminal actin depolymerization factor (ADF-H/C) domain that is homologous to a similar domain found in the actin severing protein, cofilin. Abp1 can bind Src kinases, hematopoietic progenitor kinase 1 (HPK-1), myosin I heavy chain kinase, and dynamin. Thus, Abp1 may be important for regulation of the actin cytoskeleton through its ability to interact with F-actin and various other cytoskeletal and cell signaling proteins.
Olazabal, I.M. & Machesky, L.M. (2001) J Cell Biol. 154(4):679.
Larbolette, O. et al. (1999) Mol Cell Biol. 19(2):1539.
*For more information, see UniProt Accession Q9UJU6
The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.
*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.
This kit contains: