Catalog # AM3301


Annexin A6

Mouse Monoclonal

Application Dilution
ELISA1:2000
IP1:50
WB1:1000

Size 100 μl

Species Reactivity Hu, Rt, Ms

MW 67 kDa

Isotype IgG1

$245

The Annexin family of calcium-binding proteins is composed of al least thirteen mammalian genes (Annexin A1-13). These proteins are characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner and a unique amino terminal region which may confer binding specificity. The Annexin family has been implicated as regulators of such diverse processes as ion-flux, endocytosis and exocytosis, and cellular adhesion. Annexin A2 (calpactin I, chromobindin 8, p36, Lipocortin II, PAP-IV, or Protein I) is a cytoskeletal calcium-dependent phospholipid binding protein, which has been shown to be a mediator of cortocosteroid activity, a substrate for serine/threonine kinases and growth regulated tyrosine kinases, and may play a role in secretion. Annexin A6 reverses transformation of A431 cells after overexpression, and this effect may involve annexin A6 targeting of p120 RasGAP to the plasma membrane to inactivate Ras.

 

References
Grewal, T. & Enrich, C. (2006) Bioessays 28(12):1211.
Feinberg, J.M. et al. (1991) J Histochem. & Cytochem. 39:955.
Zokas, L. & Glenney, J.R. (1987) J Cell Biol. 105:2111.
Clone (M330) was generated from a full length recombinant rat Annexin A6 protein.

*For more information, see UniProt Accession P48037
Mouse monoclonal, protein A purified antibody is supplied in 100µl phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide. Store at -20°C. Stable for 1 year.

The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.

This antibody detects a 67 kDa* protein corresponding to the molecular mass of Annexin A6 on SDS-PAGE immunoblots of human Jurkat cells.

*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blot mobilities of known proteins with similar MW.

Western blot of human Jurkat cell lysate. The blot was probed with mouse monoclonal anti-Annexin A6 antibody at 1:250 (lane 1) or 1:1000 (lane 2).



This kit contains:

KIT SUMMARY